If you've gotten a paternity test or fetal DNA test in the last twenty years, you have probably benefited from the discovery of cell-free fetal DNA, or cffDNA. This DNA is non-cellular bits of DNA floating freely in the blood stream of a pregnant woman, which can be extracted from maternal plasma and serum and tested for paternity and other genetic information.
After cffDNA was discovered, a method of detecting and interpreting it was commercialized by Sequenom and patented by Drs. Dennis Lo and James Wainscoat. Paternity and genetic tests based on cffDNA are significantly less invasive than other forms of testing. Unfortunately for Sequenom, however, those methods are also unpatentable, the Federal Circuit ruled last week.